MLL1 and menin: not partners in crime?
نویسنده
چکیده
In this issue of Blood, Li et al report an unexpected but clinically relevant finding. They demonstrate that the mixed lineage leukemia (MLL1) gene acts independently from menin (Men1) in the hematopoietic system.
منابع مشابه
Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells.
Mixed Lineage Leukemia (MLL1) translocations encode fusion proteins retaining the N terminus of MLL1, which interacts with the tumor suppressor, menin. This interaction is essential for leukemogenesis and thus is a promising drug target. However, wild-type MLL1 plays a critical role in sustaining hematopoietic stem cells (HSCs); therefore, disruption of an essential MLL1 cofactor would be expec...
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Developmental transcription programs are epigenetically regulated by the competing actions of polycomb and trithorax (TrxG) protein complexes, which repress and activate genes, respectively. Ewing sarcoma is a developmental tumor that is associated with widespread de-regulation of developmental transcription programs, including HOX programs. Posterior HOXD genes are abnormally over-expressed by...
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Multiple endocrine neoplasia type I (MEN1) is a familial cancer syndrome characterized primarily by tumors of multiple endocrine glands. The gene for MEN1 encodes a ubiquitously expressed tumor suppressor protein called menin. Menin was recently shown to interact with several components of a trithorax family histone methyltransferase complex including ASH2, Rbbp5, WDR5, and the leukemia proto-o...
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Hematopoietic stem and progenitor cells maintain blood homeostasis by giving rise to all mature blood cells and lymphocytes. A recent study identified the trithorax group gene ash1l as a critical regulator of quiescence and self-renewal potential in adult hematopoietic stem cells [1]. Ash1l encodes a large protein with histone methyltransferase activity that cooperates with the leukemia-associa...
متن کاملMenin links estrogen receptor activation to histone H3K4 trimethylation.
The product of the multiple endocrine neoplasia type 1 (MEN1) tumor suppressor gene, menin, is an integral component of MLL1/MLL2 histone methyltransferase complexes specific for Lys4 of histone H3 (H3K4). We show that menin is a transcriptional coactivator of the nuclear receptors for estrogen and vitamin D. Activation of the endogenous estrogen-responsive TFF1 (pS2) gene results in promoter r...
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عنوان ژورنال:
- Blood
دوره 122 12 شماره
صفحات -
تاریخ انتشار 2013